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PK Study for Single-dose Organizational Distribution

PK Study for Single-dose Organizational Distribution

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Study of PK in rodent tissue distribution after single administration

GLP

No

Test product

TBD

The solvent

TBD

Systematic

Species

SD rat, CD-1 mouse

Week age

according to test requirements

Weight

according to test requirements

Quantity

6/timepoint, male and female half, a total of 24 (according to test requirements)

Test dose

group

Dose

sex/quantity

Group 1

TBD

male/12, female/12,

Route of administration

IV

The frequency of administration

Single

Dosage volume

Pre-dose weighing for dosing volume calculation (daily weight recording)

Clinical observation

Symptoms were observed at each collection time point

Blood/tissue sample collection time point

0.25, 2, 8, 24 hours terminal blood collection (can be adjusted according to different requirements)

Tissue collection

Male: heart, liver, kidney, lung, spleen, stomach, intestine, brain, muscle, testicles, bladder, prostate

Female: heart, liver, kidney, lung, spleen, stomach, intestine, brain, muscle, uterus, bladder, ovary

Analytical method

LC-MS/MS

Data presentation

Mother drug concentration in different tissues at different time points


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