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The main metabolic enzymes involved in the metabolism of test subjects were screened out through metabolic pathway identification test, and their absolute or relative contributions were calculated, so as to evaluate their possible metabolic interactions.
Incubation system | Subcellular components : microsome, S9 or homogenate of liver tissue Gene recombination enzyme system |
Species | Man |
Tested enzymes | CYP450 enzymes: CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5, etc UGT enzymes: UGT1A1, 1A3, 1A4, 1A6, 1A8, 1A9, 2B7, 2B10, 2B15, 2B17, etc SULT enzymes: SULT1A1, 1A2, 1A3, 1B1, 1E1 and 2A1, etc CES enzymes: CES1 and CES2 Other: AADAC, XOD, AO, MAO, FMO, GST, ADH, ALDH and other enzymes or subtypes are available upon request |
Test concentration | To Be Determined (Different test concentration can be provided on request) |
Incubation system protein concentration | To Be Determined (different protein concentrations can be provided on request |
Incubation time | To Be Determined (available on request) |
Coenzyme factor | NADPH or UDPGA (Other Coenzyme factors are available upon request |
Analytical method | LC-MS/MS |
Data presentation | Percentage of population remaining Maternal metabolic expenditure Percentage of metabolite production Inhibition ratio Relative/absolute contribution or other parameters |