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In Vitro Study for Metabolic Pathway Identification (Phenotyping)

In Vitro Study for Metabolic Pathway Identification (Phenotyping)

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021-50800743

The main metabolic enzymes involved in the metabolism of test subjects were screened out through metabolic pathway identification test, and their absolute or relative contributions were calculated, so as to evaluate their possible metabolic interactions.

Incubation system

Subcellular components : microsome, S9 or homogenate of liver tissue

Gene recombination enzyme system

Species

Man

Tested enzymes

CYP450 enzymes: CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5, etc

UGT enzymes: UGT1A1, 1A3, 1A4, 1A6, 1A8, 1A9, 2B7, 2B10, 2B15, 2B17, etc

SULT enzymes: SULT1A1, 1A2, 1A3, 1B1, 1E1 and 2A1, etc

CES enzymes: CES1 and CES2

Other: AADAC, XOD, AO, MAO, FMO, GST, ADH, ALDH and other enzymes or subtypes are available upon request

Test concentration

To Be Determined (Different test concentration can be provided on request)

Incubation system protein concentration

To Be Determined (different protein concentrations can be provided on request

Incubation time

To Be Determined (available on request)

Coenzyme factor

NADPH or UDPGA (Other Coenzyme factors are available upon request

Analytical method

LC-MS/MS

Data presentation

Percentage of population remaining

Maternal metabolic expenditure

Percentage of metabolite production

Inhibition ratio

Relative/absolute contribution or other parameters


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