中文 English

In Vitro Study for New Ophthalmic Drugs

全国热线
021-50800743

1. Ophthalmic drugs are able to bind to melanin and accumulate in ocular tissues, causing ocular toxicity. On the other hand, the binding of ophthalmic drugs to melanin can also increase drug targeting for the delivery system of ophthalmic drugs. Therefore, studies evaluating the ability of new ophthalmic drugs to bind to melanin are essential in the development of new ophthalmic drugs.


Service

Melanin Binding

Aims

To provide a scientific basis for new drug development in ophthalmology

Testing   system

Equilibrium dialysis

Species

Melanin synthesized in vitro

Testing   concentrations

To be determined

Incubation   time

To be determined

Analytical  methods

LC-MS/MS

Parameters

(% Bound = 100 × ([Donor]-[Receiver]) /   [Donor])


2. In ophthalmic drug administration, the cornea acts as a barrier and can limit the absorption of topically administered drugs. Therefore, studies  to evaluate the permeability of new drugs in the cornea are essential in the development of new ophthalmic drugs.


Service

Corneal cell permeability test

Aims

To provide a scientific basis for new drug development in ophthalmology

Testing   system

Immortalized corneal epithelial cell

Species

Human or animal

Testing   concentrations

To be determined

Incubation   time

To be determined

Analytical  methods

LC-MS/MS

Parameters

Surface permeability (Papp)

h/l  ratio=P app(Test article)/P app(Prop)


您的信息对我们十分重要,请填写完整,以便更好的为您服务,谢谢!
更多详情

  • 上一条
  • 下一条