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PK Study for Single-dose Biliary Excretion

PK Study for Single-dose Biliary Excretion

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Study on biliary excretion PK in SD rats after single administration

 

GLP

No

Test product

TBD

The solvent

TBD

Systematic

Species

SD rat

Week age

About 6-8 weeks

Weight

180 - 350 g

Quantity

3/group, male and female half, a total of 6

Test dose

group

Dose

sex/quantity

Group 1

TBD

male/3, female/3,

Route of administration

IV

The frequency of administration

Single

Dosage volume

Pre-dose weighing for dosing volume calculation (daily weight recording)

Clinical observation

Symptoms, body weight/day and food intake/day were observed at each collection time point

Blood sample collection time point

Bile is collected 6 times within 48 hours after administration (can be adjusted according to different requirements)

Analytical method

LC-MS/MS

Data presentation

Drug recovery in bile

Concentration of 1 metabolite in the sample at each time (if any)


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