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In Vitro Study for ADC Metabolite Identification

In Vitro Study for ADC Metabolite Identification

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021-50800743

Antibody coupling drugs are composed of antibody +linker+ toxic small molecules, which have both the strong effect of traditional small molecule drugs and the targeting of antibody drugs. The main metabolites in the incubation system were evaluated by the ADC metabolite identification test, the metabolic site and metabolic pathway of payload were understood, and the reference was provided for the subsequent selection of toxicological animal species.


Name

In Vitro Study for ADC Metabolite Identification

Objective

To provide scientific basis for the development of Antibody-Drug Conjugates (ADCs)

Incubation system

Lysosome (Human), liver S9, Acidified liver S9 (Human and laboratory animals)

Species

CD1 Mice, SD rats, Beagles, crab-eating monkeys, miniature pigs, New Zealand Rabbits, Humans (other species or strains available upon request)

Test concentration

Different test concentrations are available on request

Incubation system protein concentration

Different protein concentrations are available on request

Incubation time

Available on request

Analytical method

LC-MS/MS

Data presentation

Possible metabolite structure

Mass spectrometry or UV relative abundance of metabolites

Metabolic pathway

Species differences or other parameters

 


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